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1

Macrocarpals: HIV-RTase inhibitors of Eucalyptus globulus

Mugio Nishizawa, Makoto Emura, Yukiko Kan, Hidetoshi Yamada, Koji Ogawa, Nobuyuki Hamanaka

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 329 KB

english, 1992

2

Atopic Glaucoma

Takakuwa, Kanae, Hamanaka, Teruhiko, Mori, Kazuhiko, Chin, Shinki, Shinmei, Yasuhiro, Funaki, Toshinari, Ebihara, Nobuyuki, Ono, Koichi, Murakami, Akira, Matsuda, Akira

Journal:

Journal of Glaucoma

Year:

2015

Language:

english

File:

PDF, 299 KB

english, 2015

3

Development of Epalrestat (Kinedak): Aldose Reductase Inhibitor.

KAWAMURA, Masanori, HAMANAKA, Nobuyuki

Journal:

Journal of Synthetic Organic Chemistry Japan

Year:

1997

File:

PDF, 889 KB

1997

4

ChemInform Abstract: Stereoselective Synthesis of a Set of Two Functionalized (E)-Alkene Dipeptide Isosteres of L-Amino Acid-L-Glu and L-Amino Acid-D-Glu.

Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka, Nobutaka Fujii

Journal:

Year:

2002

File:

PDF, 32 KB

2002

5

ChemInform Abstract: Diastereoselective Synthesis of ψ[(E)-CMe=CH]- and ψ[(E)-CMe=CMe]-Type Dipeptide Isosteres Based on Organocopper-Mediated anti-SN2′ Reaction.

Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka, Nobutaka Fujii

Journal:

Year:

2002

File:

PDF, 42 KB

2002

6

ChemInform Abstract: Diastereoselective Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-Type Dipeptide Isosteres by Organocopper-Mediated anti-SN2′ Reaction.

Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka, Nobutaka Fujii

Journal:

Year:

2002

File:

PDF, 35 KB

2002

7

Regio- and Stereoselective Synthesis of (E)-Alkene trans-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated anti-SN2′ Reactions.

Akira Otaka, Fumihiko Katagiri, Takayoshi Kinoshita, Yoshihiko Odagaki, Shinya Oishi, Hirokazu Tamamura, Nobuyuki Hamanaka, Nobutaka Fujii

Journal:

Year:

2003

Language:

english

File:

PDF, 283 KB

english, 2003

8

Radioiododestannylation. Convenient synthesis of a high affinity thromboxane A2/prostaglandin H2 receptor antagonist

Dale E. Mais, Perry V. Halushka, Masao Naka, Thomas A. Morinelli, John E. Oatis JR., Nobuyuki Hamanaka

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1991

Language:

english

File:

PDF, 201 KB

english, 1991

9

Cunninghamic acids A and B, novel bis(labdane)-type diterpenoids from Cunninghamia lanceolata

Hiroshi Irie, Masaaki Miyashita, Isao Kouno, Nobuyuki Hamanaka, Makiko Sugioka

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 117 KB

english, 1992

10

Basic properties of superelastic Ni-Ti alloy ligature wires for a new intermaxillary fixation method

Takayuki Yoneyama, Hisashi Doi, Hitoshi Hamanaka, Kenichi Tomitsuka, Hidemi Yoshimasu, Nobuyuki Tanaka, Teruo Amagasa

Journal:

Year:

1994

Language:

english

File:

PDF, 663 KB

english, 1994

11

Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors. I

Nobuyuki Hamanaka, Kanji Takahashi, Yuuki Nagao, Kazuhiko Torisu, Satoshi Shigeoka, Sumikazu Hamada, Hitoshi Kato, Hidekado Tokumoto, Kigen Kondo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 143 KB

english, 1995

12

Molecular design of novel PGI2 agonists without PG skeleton. IV

Nobuyuki Hamanaka, Kanji Takahashi, Yuuki Nagao, Kazuhiko Torisu, Hidekado Tokumoto, Kigen Kondo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 150 KB

english, 1995

13

Molecular design of novel PGI2 agonists without PG skeleton. III

Nobuyuki Hamanaka, Kanji Takahashi, Yuuki Nagao, Kazuhiko Torisu, Hidekado Tokumoto, Kigen Kondo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 232 KB

english, 1995

14

Synthesis of thromboxane A2 analogs—4: (±)-Dithiathromboxane A2 sodium salt

Shuichi Ohuchida, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Year:

1983

Language:

english

File:

PDF, 825 KB

english, 1983

15

Synthesis of thromboxane A2 analogs—3: (+)-Thiathromboxane A2

Shuichi Ohuchida, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Year:

1983

Language:

english

File:

PDF, 410 KB

english, 1983

16

Synthesis of thromboxane A2 analogs—1: (±)-Dimethanothromboxane A2

Shuichi Ohuchida, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Year:

1983

Language:

english

File:

PDF, 503 KB

english, 1983

17

The structure of prostaglandin B1 dimer

Masaaki Toda, Shigeru Takaoka, Mitoshi Konno, Shigehiro Okuyama, Masaki Hayashi, Nobuyuki Hamanaka, Takashi Iwashita

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 214 KB

english, 1982

18

Synthesis of 9α,11α-thiathromboxane A2 methyl ester

Shuichi Ohuchida, Nobuyuki Hamanaka, Shinsuke Hashimoto, Masaki Hayashi

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 225 KB

english, 1982

19

Synthesis of thromboxane A2 analog, dl-(9,11)-methano-(11,12)-amino thromboxane A2

Shunji Kosuge, Masaki Hayashi, Nobuyuki Hamanaka

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 220 KB

english, 1982

20

Structural elucidation of epalrestat(ONO-2235), a potent aldose reductase inhibitor, and isomerization of its double bonds

Toshimasa Ishida, Yasuko In, Masatoshi Inoue, Yoko Ueno, Chiaki Tanaka, Nobuyuki Hamanaka

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 277 KB

english, 1989

21

Synthesis of clavulones (claviridenones)

Shinsuke Hashimoto, Yoshinobu Arai, Nobuyuki Hamanaka

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 201 KB

english, 1985

22

The synthesis of potent thromboxane A2/ prostaglandin endoperoxide receptor antagonist

Nobuyuki Hamanaka, Takuya Seko, Tohru Miyazaki, Masao Naka, Kyoji Furuta, Hisashi Yamamoto

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 237 KB

english, 1989

23

Partial Synthesis of Grayanotoxin

Nobuyuki Hamanaka, Takeshi Matsumoto

Journal:

Tetrahedron Letters

Year:

1972

Language:

english

File:

PDF, 209 KB

english, 1972

24

Synthesis of thromboxane A2 analog DL-(9,11), (11,12)-dideoxa-(9,11)-methylene-(11,12)-epithio-thromboxane A2 methyl ester

Shunji Kosuge, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 196 KB

english, 1981

25

Synthesis of thromboxane A2 analog DL-(9,11), (11,12)-dideoxa-(9,11)-epithio-(11,12)-methylene-thromboxane A2

Shuichi Ohuchida, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 263 KB

english, 1981

26

A convenient route to (+)-(9,11)-epithia-(11,12)-methano-thromboxane A2, from prostaglandin E2, methyl ester

Shuichi Ohuchida, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 119 KB

english, 1981

27

Isolation and structure of a mycosporine from the red alga chondrus yendoi

Isami Tsujino, Kazuo Yabe, Isao Sekikawa, Nobuyuki Hamanaka

Journal:

Tetrahedron Letters

Year:

1978

Language:

english

File:

PDF, 323 KB

english, 1978

28

Synthesis of thromboxane A2 analog dl-(9,11),(11,12)-dideoxa-(9,11),(11,12)-dimethylene thromboxane A2

Shuichi Ohuchida, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 215 KB

english, 1979

29

Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity

Hirokazu Tamamura, Makiko Sugioka, Yoshihiko Odagaki, Akane Omagari, Yukiko Kan, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Stephen C Peiper, Nobuyuki Hamanaka, Akira Otaka, Nobutaka Fujii

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 231 KB

english, 2001

30

Corrigendum to “conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity”: [Bioorg. Med. Chem. Lett. 11 (2001) 359]

Hirokazu Tamamura, Makiko Sugioka, Yoshihiko Odagaki, Akane Omagari, Yukiko Kan, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Nobuyuki Hamanaka, Akira Otaka, Nobutaka Fujii

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 130 KB

english, 2001

31

Synthesis of structural analogues of leukotriene B4 and their receptor binding activity

Mitoshi Konno, Takahiko Nakae, Shigeru Sakuyama, Minoru Nishizaki, Yoshihiko Odagaki, Hisao Nakai, Nobuyuki Hamanaka

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 2.44 MB

english, 1997

32

Trisubstituted benzene leukotriene B4 receptor antagonists: Synthesis and structure-activity relationships

Mitoshi Konno, Takahiko Nakae, Shigeru Sakuyama, Yoshihiko Odagaki, Hisao Nakai, Nobuyuki Hamanaka

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 2.37 MB

english, 1997

33

Molecular design of novel PGI2 agonists without PG skeleton. II

Nobuyuki Hamanaka, Kanji Takahashi, Yuuki Nagao, Kazuhiko Torisu, Hideo Takada, Hidekado Tokumoto, Kigen Kondo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 251 KB

english, 1995

34

Molecular design of novel PGI2 agonists without PG skeleton. I

Nobuyuki Hamanaka, Kanji Takahashi, Yuuki Nagao, Kazuhiko Torisu, Hidekado Tokumoto, Kigen Kondo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 249 KB

english, 1995

35

Synthesis of thromboxane A2 analogs—2: (±)-Thiathromboxane A2

Shuichi Ohuchida, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Year:

1983

Language:

english

File:

PDF, 696 KB

english, 1983

36

Relay total synthesis of grayanotoxin II

Shinsei Gasa, Nobuyuki Hamanaka, Seiji Matsunaga, Toshikatsu Okuno, Naoki Takeda, Takeshi Matsumoto

Journal:

Tetrahedron Letters

Year:

1976

Language:

english

File:

PDF, 214 KB

english, 1976

37

Synthesis of nitrogen-containing prostaglandin I1 analogs

Hisao Nakai, Yoshinobu Arai, Nobuyuki Hamanaka, Masaki Hayashi

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 176 KB

english, 1979

38

Clarification of Mechanism of Human Sputum Elastase Inhibition by a New Inhibitor, ONO-5046, Using Electrospray Ionization Mass Spectrometry

Yoshisuke Nakayama, Yoshihiko Odagaki, Setsuko Fujita, Shozo Matsuoka, Nobuyuki Hamanaka, Hisao Nakai, Masaaki Toda

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 128 KB

english, 2002

39

Effects of human apolipoprotein E isoforms on the amyloid β-protein concentration and lipid composition in brain low-density membrane domains

Maho Morishima-Kawashima, Xianlin Han, Yu Tanimura, Hiroki Hamanaka, Mariko Kobayashi, Takashi Sakurai, Minesuke Yokoyama, Koji Wada, Nobuyuki Nukina, Shinobu C. Fujita, Yasuo Ihara

Journal:

Journal of Neurochemistry

Year:

2007

Language:

english

File:

PDF, 685 KB

english, 2007

40

Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid

Toshiaki Minami, Shinji Matsumura, Mikio Nishizawa, Yasuyuki Sasaguri, Nobuyuki Hamanaka, Seiji Ito

Journal:

British Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 299 KB

english, 2004

41

Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists

Habashita, Hiromu, Kokubo, Masaya, Hamano, Shin-ichi, Hamanaka, Nobuyuki, Toda, Masaaki, Shibayama, Shiro, Tada, Hideaki, Sagawa, Kenji, Fukushima, Daikichi, Maeda, Kenji

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 201 KB

english, 2006

42

Photo-degradation products of pramipexole

Eiji Nishimura, Aya Kugimiya, Hideo Naoki, Nobuyuki Hamanaka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 565 KB

english, 2012

43

Interaction of Mutagenic Tryptophan Pyrolysate with d(CGATCG)2: Intercalation Model Based on NMR Experiments

Yoshitetsu Mihara, Mitsunobu Doi, Takeo Inohara, Masanori Kawamura, Nobuyuki Hamanaka, Toshimasa Ishida

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 147 KB

english, 1997

44

Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture

Akio Morimoto, Kazuki Okamura, Ryoji Hamanaka, Yasufumi Sato, Nobuyuki Shima, Kanji Higashio, Michihiko Kuwano

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 1.65 MB

english, 1991

45

Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae

Kazumi Hiraga, Shogo Yamamoto, Hiroyuki Fukuda, Nobuyuki Hamanaka, Kohei Oda

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 418 KB

english, 2005

46

A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae

Shogo Yamamoto, Kazumi Hiraga, Atsushi Abiko, Nobuyuki Hamanaka, Kohei Oda

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 439 KB

english, 2005

47

Synthesis of 8,9-leukotriene A4 by murine 8-lipoxygenase

Hiroo Kawajiri, Yingshi Piao, Yoshitaka Takahashi, Takashi Murakami, Nobuyuki Hamanaka, Tanihiro Yoshimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 161 KB

english, 2005

48

Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E

Hiroyuki W. Kitamura, Hiroki Hamanaka, Masahiko Watanabe, Koji Wada, Chiharu Yamazaki, Shinobu C. Fujita, Toshiya Manabe, Nobuyuki Nukina

Journal:

Neuroscience Letters

Year:

2004

Language:

english

File:

PDF, 249 KB

english, 2004

49

Inhibition of ubiquitin ligase Siah-1A by disabled-1

Tae-Ju Park, Hiroki Hamanaka, Toshio Ohshima, Noriko Watanabe, Katsuhiko Mikoshiba, Nobuyuki Nukina

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 369 KB

english, 2003

50

P-435 High-resolution CT analysis of resected small adenocarcinoma and atypical adenomatous hyperplasia(AAH) less than 10mm in diameter with correlation to the pathological findings

Saito, Haruhiro, Yamada, Kouzo, Hamanaka, Nobuyuki, Suzuki, Rie, Oshita, Fumihiro, Nakayama, Haruhiko, Mitsuda, Aki, Kameda, Youichi, Noda, Kazumasa

Journal:

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003